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MDL 28170: Advancing Neurodevelopmental and Cardiac Resea...
2026-01-12
Explore how MDL 28170, a selective calpain and cathepsin B inhibitor, is reshaping neuroprotection and cardiac injury research by targeting synaptic plasticity and cellular survival pathways. This article uncovers new mechanistic insights and translational applications beyond standard models.
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MDL 28170: Selective Calpain Inhibitor for Advanced Neuro...
2026-01-12
MDL 28170 delivers nanomolar potency and unmatched selectivity for calpain and cathepsin B inhibition, enabling precise modulation of cysteine protease signaling in neuroprotection, cardiac injury, and parasitology models. Its robust blood-brain barrier penetration and membrane permeability set it apart for translational disease research and apoptosis workflows. APExBIO’s MDL 28170 empowers reproducibility, mechanistic clarity, and innovation at every experimental step.
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Tetrandrine Alkaloid: Precision Calcium Channel Blocker f...
2026-01-11
Tetrandrine sets a new standard for cell signaling and ion channel modulation studies, combining robust DMSO solubility and high purity for reproducible neuroscience and cancer biology research. APExBIO’s Tetrandrine empowers advanced workflows with actionable troubleshooting advantages and proven performance as an anti-inflammatory, immunomodulatory compound.
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Z-DEVD-FMK: Irreversible, Cell-Permeable Caspase-3 Inhibi...
2026-01-10
Z-DEVD-FMK is a potent, cell-permeable, irreversible caspase-3 inhibitor widely used in apoptosis assays and neurodegenerative disease models. Its dual inhibition of caspases and calpain enables precise dissection of cell death pathways and supports robust neuroprotective and cancer research applications.
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MDL 28170 (Calpain and Cathepsin B Inhibitor, Selective):...
2026-01-09
This article addresses real-world laboratory challenges in cell viability, apoptosis, and neuroprotection workflows by exploring the data-backed advantages of MDL 28170 (Calpain and Cathepsin B Inhibitor, Selective; SKU A4412). Bench scientists will discover scenario-driven guidance on experimental design, protocol optimization, and product reliability, with emphasis on reproducibility and selectivity for cysteine protease inhibition.
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Protease and Phosphatase Inhibitor Cocktail: Precision in...
2026-01-09
Unlock robust protein integrity and phosphorylation preservation with the APExBIO Protease and Phosphatase Inhibitor Cocktail (EDTA Free, 100X in ddH2O). This advanced, metal-chelator-free solution empowers researchers to capture authentic post-translational modifications—even in complex cell and tissue samples—while streamlining workflows in proteomics and cell signaling research.
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Probenecid: Strategic MRP Inhibitor for Multidrug Resista...
2026-01-08
Probenecid stands apart as a multidimensional tool in cancer, neuroprotection, and immunometabolic research, thanks to its unique inhibition of organic anion transporters, MRPs, and pannexin-1 channels. Applied in robust experimental workflows, it enhances chemosensitivity, optimizes efflux assays, and empowers the discovery of transporter-mediated cellular mechanisms. Discover how APExBIO’s Probenecid (4-(dipropylsulfamoyl)benzoic acid) can elevate your research outcomes through strategic protocol integration and troubleshooting insight.
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Tetrandrine Alkaloid: Precision Calcium Channel Blocker f...
2026-01-07
Tetrandrine is a well-characterized calcium channel blocker for research, valued for its high purity and robust DMSO solubility. This compound is employed in neuroscience, cell signaling, and cancer biology studies, where its efficacy as an ion channel modulator is supported by mechanistic evidence. Researchers rely on Tetrandrine for reproducible results in cell signaling pathway modulation and membrane transporter inhibition.
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KN-62 and the CaMKII Pathway: Strategic Advances in Calci...
2026-01-06
This thought-leadership article explores the mechanistic, experimental, and translational dimensions of KN-62, a potent and selective CaMKII inhibitor. We synthesize recent advances in calcium signaling, memory research, and metabolic regulation, providing actionable insights for researchers seeking to harness KN-62 as a catalyst in disease modeling and therapeutic discovery. Drawing on foundational studies—including new revelations about synaptic plasticity and memory maintenance—we map out a strategic blueprint for leveraging APExBIO’s KN-62 in next-generation translational research.
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Ionomycin Calcium Salt: Mechanisms, Evidence & Applicatio...
2026-01-05
Ionomycin calcium salt is a potent calcium ionophore used to increase intracellular Ca2+ concentrations, driving research in apoptosis and tumor inhibition. As a benchmark tool for calcium signaling pathway studies, it modulates Bcl-2/Bax ratios and has demonstrated in vivo tumor growth suppression. This article details its molecular mechanisms, experimental benchmarks, and translational impact in human bladder cancer and related models.
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E-64: Potent L-trans-Epoxysuccinyl Peptide Cysteine Prote...
2026-01-04
E-64 is a well-characterized, potent, and irreversible L-trans-epoxysuccinyl peptide cysteine protease inhibitor. It enables precise cysteine protease inhibition and cathepsin inhibition in mechanistic studies, supporting reproducible research in cancer, signaling, and cell death pathways.
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Leupeptin Hemisulfate Salt: Precision in Protease Activit...
2026-01-03
Leupeptin hemisulfate salt (SKU: A2570) from APExBIO empowers researchers with unrivaled precision in serine and cysteine protease inhibition, enabling robust workflows in protein degradation, viral replication studies, and macroautophagy research. This article bridges cutting-edge protocols with troubleshooting insights to maximize data reliability and experimental reproducibility.
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Tetrandrine Alkaloid: Pioneering Ion Channel Modulation i...
2026-01-02
Tetrandrine alkaloid from APExBIO redefines precision in ion channel modulation studies, offering robust, reproducible tools for neuroscience, cancer biology, and immunomodulation research. Its high purity, unique solubility, and multifaceted bioactivity empower researchers to bridge mechanistic insights with translational breakthroughs.
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Leupeptin Hemisulfate Salt (A2570): Precision Serine and ...
2026-01-01
Leupeptin hemisulfate salt is a reversible, competitive inhibitor of serine and cysteine proteases, enabling rigorous control of protease activity in biochemical research. Its high specificity and well-characterized inhibition kinetics make it indispensable for studies of protein degradation, viral replication inhibition, and macroautophagy. APExBIO supplies this compound (SKU: A2570) at 98% purity, supporting reproducible, high-impact workflows.
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Gap26 Connexin 43 Mimetic Peptide: Precise Gap Junction B...
2025-12-31
Gap26 is a connexin 43 mimetic peptide that functions as a selective gap junction blocker peptide, widely used for modulating calcium signaling and ATP release in cellular and animal models. Its specificity for connexin 43 hemichannels enables reproducible inhibition of intercellular communication, supporting research in neuroprotection and vascular smooth muscle physiology.